Nursing interventions in palliative care and quality of life in cancer patients: a systematic review

Authors

DOI:

https://doi.org/10.47606/ACVEN/MV0340

Keywords:

Palliative care, oncology nursing, ; quality of life, cancer, comprehensive care, systematic review.

Abstract

Introduction: Palliative care alleviates suffering and improves the quality of life of cancer patients through comprehensive care, in which nursing plays a fundamental role within the interdisciplinary team. Objective: To analyze nursing interventions in palliative care and their impact on the quality of life of cancer patients. Materials and Methods: A systematic review was conducted following the PRISMA 2020 guidelines. The search was performed in the PubMed/MEDLINE, Scopus, Web of Science, and SciELO databases. Articles published between 2021 and 2025 in English, Spanish, and Portuguese were considered. The protocol was registered with PROSPERO under number CRD420261437426. A total of 612 records were identified, and after the screening and eligibility process, 20 studies were included. Methodological quality and risk of bias were assessed using checklists from the Joanna Briggs Institute. Results: Nursing-led interventions showed positive effects on the management of physical symptoms, emotional coping, therapeutic communication, and continuity of care. Studies with a low or moderate risk of bias predominated. The most effective interventions were early palliative care, educational and psychoeducational interventions, structured telephone follow-up, advance care planning, and care coordination. Conclusions: Nursing interventions in palliative care are critical to the well-being and quality of life of cancer patients. The heterogeneity in the methodology of the included studies highlights the need to conduct research with more robust designs to strengthen evidence-based clinical practice.

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References

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022. CA Cancer J Clin. 2024;74(3):229-263. doi:10.3322/caac.21834

Organización Mundial de la Salud. Cuidados paliativos [Internet]. Ginebra: Organización Mundial de la Salud; 2020 [actualizado 20 ago 2020]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/palliative-care

Hui D, Bohlke K, Bao T, Campbell TC, Coyne PJ, Currow DC, et al. Management of Dyspnea in Advanced Cancer: ASCO Guideline. J Clin Oncol. 20 de abril de 2021;39(12):1389-1411. Disponible en: https://ascopubs.org/doi/full/10.1200/JCO.20.03465 doi: 10.1200/JCO.20.03465

Fayers PM, Machin D. Quality of Life: The Assessment, Analysis and Interpretation of Patient-Reported Outcomes. 3rd ed. Wiley; 2022.

Grenon NN, Waldrop KS, Pinheiro N, Prosdocimo B. The evolving role of the oncology nurse in the United States of America: A survey exploring their perspective. Healthcare (Basel). 2024;12(23):2453. doi:10.3390/healthcare12232453.

Gunawan J, Aungsuroch Y, Watson J, Marzilli C. Nursing Administration: Watson's Theory of Human Caring. Nurs Sci Q. 2022;35(2):235-243. doi:10.1177/08943184211070582

Sanders JJ, Temin S, Ghoshal A, Alesi ER, Ali ZV, Chauhan C, et al. Palliative Care for Patients With Cancer: ASCO Guideline Update. J Clin Oncol. 2024;42(19):2336-2357. doi:10.1200/JCO.24.00542

Schenker Y, Althouse AD, Rosenzweig M, White DB, Chu E, Smith KJ, et al. Effect of an Oncology Nurse-Led Primary Palliative Care Intervention on Patients With Advanced Cancer: The CONNECT Cluster Randomized Clinical Trial. JAMA Intern Med. 2021;181(11):1451-1460. doi:10.1001/jamainternmed.2021.5185

Reinke LF, Tartaglione EV, Ruedebusch S, Sullivan DR, Dobler CC, Blinderman CD, et al. Nurse-Led Telephone-Based Primary Palliative Care Intervention. J Hosp Palliat Nurs. 2024;26(2):104-111. doi:10.1097/NJH.0000000000001005

Abu-Odah H, Leung D, Chan EA, Bayuo J, Su JJ, Ho KY, et al. Oncology nurses' lived experience of caring for patients with palliative care needs. Int J Palliat Nurs. 2024;30(7):370-378. doi:10.12968/ijpn.2024.30.7.370

Kang E, Kang JH, Koh SJ, Kim YJ, Seo S, Kim JH, et al. Early Integrated Palliative Care for Patients With Advanced Cancer. JAMA Netw Open. 2024;7(8):e2426304. doi:10.1001/jamanetworkopen.2024.26304

Pastrana T, De Lima L, Wenk R, Eisenchlas J, Rocafort J, Centeno C, et al. Atlas de cuidados paliativos en Latinoamérica 2020 [Internet]. Houston: International Association for Hospice and Palliative Care; 2021 [citado 2026 Jun 6]. Disponible en: https://cuidadospaliativos.org/uploads/2021/8/Atlas%20de%20Cuidados%20Paliativos%20en%20Latinoamerica%202020.pdf

Arias-Rojas M, Arredondo-Holguín E, Carreño-Moreno S. Efficacy of the “PalliActive Caregivers” intervention for caregivers of patients with cancer in palliative care. BMC Palliat Care. 2025;24(1):235. doi:10.1186/s12904-025-01885-1

Choi YY, Hong B, Rha SY, Cho S, Lee HS, Lee J. The effect of nurse-led enhanced supportive care as an early primary palliative care approach for patients with advanced cancer: a randomized controlled trial. Int J Nurs Stud. 2025;168:105102. doi:10.1016/j.ijnurstu.2025.105102

De Vleminck A, Matthys O, Turola E, Dierickx S, Dombrecht L, Van Goethem V, et al. Impact of a nurse-led and a web-based psychoeducational program for advanced cancer patients and their caregivers: Results of a three-arm randomized controlled trial. Int J Nurs Stud. 2025;105192. doi:10.1016/j.ijnurstu.2025.105192

Lelond S, Kim CA. Advanced practice nurse-led early palliative care: a novel model for improved access to care. Support Care Cancer. 2025;33(3):168. doi:10.1007/s00520-025-09193-3

Sato T, Manaka H, Kodama M, Nieda R, Kawamura Y, Yamamoto M, et al. A Feasibility Randomized Controlled Trial of Nurse-Led Screening-Based Early Care Program from the Time of Diagnosis for Patients with Advanced Lung Cancer and Their Caregivers. Palliat Med Rep. 2025;6(1):[completar páginas o número de artículo si aparece en la publicación]. doi:10.1089/pmr.2025.0018

Gerhardt S, Benthien KS, Herling S, Villumsen M, Krarup PM. Palliative care case management in a surgical department for patients with gastrointestinal cancer: a register-based cohort study. Support Care Cancer. 2024;32(9):598. doi:10.1007/s00520-024-08794-8

Greer JA, Post KE, Chabria R, Aribindi S, Brennan N, Eche-Ugwu IJ, et al. Randomized Controlled Trial of a Nurse-Led Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer. J Clin Oncol. 2024;42(30):3570-3580. doi:10.1200/JCO.24.00048

Li X, Hu S, Zhou Y, Ying X, Wu T. Impact of nurse-led palliative care on symptom management and life quality outcomes in elderly cancer patients: a retrospective study. Medicine (Baltimore). 2024;103(40):e39817. doi:10.1097/MD.0000000000039817

Matsumoto Y, Umemura S, Okizaki A, Fujisawa D, Yamaguchi T, Oyamada S, et al. Nurse-Led Screening-Triggered Early Specialized Palliative Care Program for Patients With Advanced Lung Cancer: A Multicenter Randomized Controlled Trial. Cancer Med. 2024;13:e70325. doi:10.1002/cam4.70325

Cohen MG, Althouse AD, Arnold RM, White D, Chu E, Rosenzweig M, et al. Primary Palliative Care Improves Uptake of Advance Care Planning Among Patients With Advanced Cancers. J Natl Compr Canc Netw. 2023;21(8):821-828. doi:10.6004/jnccn.2023.7002

Gerhardt S, Leerhøy B, Jarlbæk L, Herling SF. Qualitative evaluation of a palliative care case management intervention for patients with incurable gastrointestinal cancer. Eur J Oncol Nurs. 2023;66:102409. doi:10.1016/j.ejon.2023.102409

Valenti V, Rossi R, Scarpi E, Ricci M, Pallotti MC, Dall'Agata M, et al. Nurse-led telephone follow-up for early palliative care patients with advanced cancer. J Clin Nurs. 2023;32(23-24):7743-7752. doi:10.1111/jocn.16403

Yamarik RL, Chiu LA, Flannery M, Van Allen K, Adeyemi O, Cuthel AM, et al. Engagement, Advance Care Planning, and Hospice Use in a Telephonic Nurse-Led Palliative Care Program for Persons Living with Advanced Cancer. Cancers (Basel). 2023;15(8):2310. doi:10.3390/cancers15082310

Chung V, Sun V, Ruel N, Smith TJ, Ferrell BR. Improving palliative care and quality of life in pancreatic cancer patients. J Palliat Med. 2022;25(5):720-727. doi:10.1089/jpm.2021.0187

Sigler LE, Althouse AD, Thomas TH, Arnold RM, White D, Smith TJ, et al. Effects of an Oncology Nurse-Led, Primary Palliative Care Intervention (CONNECT) on Illness Expectations Among Patients With Advanced Cancer. JCO Oncol Pract. 2022;18(4):e541-e549. doi:10.1200/OP.21.00573

Xu M, Zhu L, Yang J. Nurse-led cancer palliative care compared to oncologist-led cancer palliative care: A retrospective analysis of Chinese patients suffering from cancer and receiving chemotherapy. Adv Clin Exp Med. 2022;31(10):1081-1086. doi:10.17219/acem/149915

Zhang A, Fu H. The impact of palliative care and nursing intervention on the psychology and quality of life of elderly patients with colorectal cancer. J Oncol. 2022;2022:7777446. doi:10.1155/2022/7777446

Published

2026-07-20

How to Cite

Suquilanda Oña, G. E. ., & Saltos Llerena , I. J. . . (2026). Nursing interventions in palliative care and quality of life in cancer patients: a systematic review. Más Vita, 8(3), 62–78. https://doi.org/10.47606/ACVEN/MV0340

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Original Articles